Articles
IN VIVO ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECTS OF MALVA PARVIFLORA LEAF EXTRACTS
Article number
854_2
Pages
23 – 30
Language
English
Abstract
The anti-inflammatory and antioxidant effects of Malva parviflora leaf extracts were evaluated in this study.
Results showed that the oral administration of 500 mg/kg of methanolic extract or 360 mg/kg of aqueous extract inhibited significantly the xylene induced ear oedema in mice.
In the same way, the oral administration of methanolic extract and aqueous extract at 500 and 360 mg/kg, exerted 36% and 40% of inhibition respectively of acetic acid induced vascular permeability in mice.
These effects were statistically similar to the effect of indomethacin which is a standard anti-inflammatory drug.
The antioxidant effect of Malva parviflora leaf extracts was also assessed using total antioxidant capacity test in mice.
The daily administration of methanolic extract and aqueous extract during three weeks showed significant and dose dependent improvement of the blood total antioxidant capacity.
Taken together, we conclude that Malva parviflora leaf extracts possess anti-inflammatory and antioxidant activities which support its traditional uses in the treatment of inflammatory disorders.
Results showed that the oral administration of 500 mg/kg of methanolic extract or 360 mg/kg of aqueous extract inhibited significantly the xylene induced ear oedema in mice.
In the same way, the oral administration of methanolic extract and aqueous extract at 500 and 360 mg/kg, exerted 36% and 40% of inhibition respectively of acetic acid induced vascular permeability in mice.
These effects were statistically similar to the effect of indomethacin which is a standard anti-inflammatory drug.
The antioxidant effect of Malva parviflora leaf extracts was also assessed using total antioxidant capacity test in mice.
The daily administration of methanolic extract and aqueous extract during three weeks showed significant and dose dependent improvement of the blood total antioxidant capacity.
Taken together, we conclude that Malva parviflora leaf extracts possess anti-inflammatory and antioxidant activities which support its traditional uses in the treatment of inflammatory disorders.
Authors
H. Bouriche, H. Meziti, A. Senator
Keywords
Malvaceae, inflammation, oedema, vascular permeability, exudation
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