Articles
USING AGING RATS MODEL TO INVESTIGATE ANTI-OXIDATIVE ABILITY OF ARTICHOKE (CYNARA SCOLYMUS L.) LEAF EXTRACT
Article number
944_15
Pages
113 – 122
Language
English
Abstract
Artichoke (Cynara scolymus L.), originated in the Mediterranean areas, is a kind of vegetable with high nutritional and health value.
Varieties of bioactive substances existing in artichoke contribute to the physiological effects in treating dyspeptic disorder, protecting the liver, anti-oxidation activities, cardiovascular protection and others.
To study the influence of artichoke on the anti-oxidative function of D-galactose induced aging rats, fifty SD rats were divided into five groups: control group, aging model group, low, middle, high dosage of artichoke treatment groups.
Except the control group, all other groups were injected with
D-galactose solution (40 mg/kg BW) daily for successive 36 days.
At the same time, rats in the artichoke treatment groups were orally given artichoke in the dosage of 20, 40, 80 mg/kg respectively.
Finally, body weight, Hematology parameters, SOD (superoxide dismutase), GSH-Px (glutathione peroxidase), CAT (catalase) activities and the content of MDA (malondialdehyde) and LF (lipofusion) in serum, liver and brain were detected.
The results showed that the activity of SOD in brain, liver, GSH-Px in brain, CAT in liver increased significantly compared with aging model group, while the content of MDA in serum, LF in brain and liver decreased significantly.
Varieties of bioactive substances existing in artichoke contribute to the physiological effects in treating dyspeptic disorder, protecting the liver, anti-oxidation activities, cardiovascular protection and others.
To study the influence of artichoke on the anti-oxidative function of D-galactose induced aging rats, fifty SD rats were divided into five groups: control group, aging model group, low, middle, high dosage of artichoke treatment groups.
Except the control group, all other groups were injected with
D-galactose solution (40 mg/kg BW) daily for successive 36 days.
At the same time, rats in the artichoke treatment groups were orally given artichoke in the dosage of 20, 40, 80 mg/kg respectively.
Finally, body weight, Hematology parameters, SOD (superoxide dismutase), GSH-Px (glutathione peroxidase), CAT (catalase) activities and the content of MDA (malondialdehyde) and LF (lipofusion) in serum, liver and brain were detected.
The results showed that the activity of SOD in brain, liver, GSH-Px in brain, CAT in liver increased significantly compared with aging model group, while the content of MDA in serum, LF in brain and liver decreased significantly.
Authors
Shuhui Song, Lin Zhao, Li Feng, Wenqi Wang, Tao Cong, Hongju He
Keywords
Cynara scolymus L., artichoke leaf extract, D-galactose, SD rats, antioxidant enzymes, MDA, LF
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