Articles
Pharmacognosy of Centipeda cunninghamii, an endemic Australian traditional medicinal plant
Article number
1125_6
Pages
47 – 56
Language
English
Abstract
Centipeda is a genus in the family Asteraceae comprising 12 taxa in 10 species.
All but one species occur in Australia.
There are documented traditional medicinal uses of five species across Australia, India and China.
Investigations of the aqueous ethanolic extract of C. cunninghamii (DC) A. Braun & Asch. have confirmed its anti-inflammatory and antioxidant (ORAC) activity.
Detailed investigations suggest that the extract acts against a range of inflammatory markers including; PGE2 COX, NO and TNF-α, but not through the lipoxygenase pathway.
Seventeen compounds were isolated and subsequent bioassays indicated that the anti-inflammatory activity was linked to flavonoids and terpenoids, whilst the antioxidant activity was attributed to both flavonoids and a group of novel heptenedioic acid caffeoyl esters.
Quality control for medicinal plant production of this species has utilised the levels of phenolics, flavonoids and sequiterpenes to optimise growing and extraction parameters.
All but one species occur in Australia.
There are documented traditional medicinal uses of five species across Australia, India and China.
Investigations of the aqueous ethanolic extract of C. cunninghamii (DC) A. Braun & Asch. have confirmed its anti-inflammatory and antioxidant (ORAC) activity.
Detailed investigations suggest that the extract acts against a range of inflammatory markers including; PGE2 COX, NO and TNF-α, but not through the lipoxygenase pathway.
Seventeen compounds were isolated and subsequent bioassays indicated that the anti-inflammatory activity was linked to flavonoids and terpenoids, whilst the antioxidant activity was attributed to both flavonoids and a group of novel heptenedioic acid caffeoyl esters.
Quality control for medicinal plant production of this species has utilised the levels of phenolics, flavonoids and sequiterpenes to optimise growing and extraction parameters.
Authors
D.N. Leach, R.N. Spooner-Hart, K.D. Beattie
Keywords
HPLC analysis, anti-inflammatory, antioxidant, traditional medicine, chemical constituents
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