Articles
Biological performance of Olyset® Plus, a long-lasting mosquito net incorporating a mixture of a pyrethroid and synergist
Article number
1169_12
Pages
77 – 82
Language
English
Abstract
In the past 10 years, long-lasting insecticide-treated bed nets (LLINs) have made impressive gains in the fight against malaria.
The spread of pyrethroid-resistant malaria vector mosquitoes, Anopheles spp., particularly in Africa, threatens to undermine these gains, causing serious risks to public health.
Therefore, new methods are urgently needed in order to ensure continued progress in controlling the transmission of malaria.
Olyset® Plus was developed to provide improved performance against resistant vectors.
This polyethylene bed net contains 2% (w/w) permethrin combined with 1% (w/w) of the synergist piperonyl butoxide (PBO). These chemicals rapidly regenerate after washing.
Olyset® Plus showed greater efficacy than a variant without PBO against pyrethroid-resistant Culex quinquefasciatus in the laboratory as well as against Anopheles gambiae in extensive field trials in Africa.
The efficacy of Olyset® Plus was also significantly greater than that of a commercially available LLIN against field-collected pyrethroid-resistant An. arabiensis in western Kenya.
This LLIN may be a valuable tool for the control, elimination, and ultimate eradication of malaria.
Olyset® Plus gained a WHO interim recommendation in 2012. Olyset® is a registered trademark of Sumitomo Chemical Company, Ltd.
The spread of pyrethroid-resistant malaria vector mosquitoes, Anopheles spp., particularly in Africa, threatens to undermine these gains, causing serious risks to public health.
Therefore, new methods are urgently needed in order to ensure continued progress in controlling the transmission of malaria.
Olyset® Plus was developed to provide improved performance against resistant vectors.
This polyethylene bed net contains 2% (w/w) permethrin combined with 1% (w/w) of the synergist piperonyl butoxide (PBO). These chemicals rapidly regenerate after washing.
Olyset® Plus showed greater efficacy than a variant without PBO against pyrethroid-resistant Culex quinquefasciatus in the laboratory as well as against Anopheles gambiae in extensive field trials in Africa.
The efficacy of Olyset® Plus was also significantly greater than that of a commercially available LLIN against field-collected pyrethroid-resistant An. arabiensis in western Kenya.
This LLIN may be a valuable tool for the control, elimination, and ultimate eradication of malaria.
Olyset® Plus gained a WHO interim recommendation in 2012. Olyset® is a registered trademark of Sumitomo Chemical Company, Ltd.
Publication
Authors
Y. Shono, K. Ohashi, J.R. Lucas
Keywords
malaria, vector control, long-lasting insecticidal net, pyrethroid resistance, Olyset Net
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