Articles
ADDITIVE INHIBITORY EFFECT OF SAFFRON IN COMBINATION WITH SODIUM SELENITE ON TUMOR CELLS
Article number
650_58
Pages
477 – 484
Language
English
Abstract
Both saffron and selenium have been reported to exhibit antigenotoxic and cancer chemopreventive activities.
We have examined the effects of naturally occurring saffron extracts in combination with sodium selenite on colony formation and nucleic acid synthesis of different human cultured malignant cells.
Results of these experiments demonstrated that saffron in combination with sodium selenite displays an additive inhibitory effect on colony formation and nucleic acid synthesis in tumor cells at low concentrations of both agents.
These results suggest the potential use of saffron as an anticancer agent, alone or in combination with sodium selenite.
We have examined the effects of naturally occurring saffron extracts in combination with sodium selenite on colony formation and nucleic acid synthesis of different human cultured malignant cells.
Results of these experiments demonstrated that saffron in combination with sodium selenite displays an additive inhibitory effect on colony formation and nucleic acid synthesis in tumor cells at low concentrations of both agents.
These results suggest the potential use of saffron as an anticancer agent, alone or in combination with sodium selenite.
Authors
L. Riverón-Negrete, R. Camacho-Carranza, H. Caballero-Ortega, J.M. Hernández, M. Medécigo-Ríos, A. Castillo-Villanueva, I. Pérez-López, J.J. Espinosa-Aguirre, F. Abdullaev
Keywords
chemoprevention, Crocus sativus L., cytotoxicity, DNA and RNA synthesis
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