Articles
INVOLVEMENT OF GABA IN NOOTROPIC AND ANXIOLYTIC ACTIVITY OF SAPONINS OF ALBIZZIA LEBBECK LEAVES
Article number
675_16
Pages
115 – 121
Language
English
Abstract
The effect of saponin containing n-butanolic fraction (BF) extracted from dried leaves of Albizzia lebbeck was studied on cognitive behavior and anxiety in albino mice.
An elevated plus maze was used for assessment of both nootropic and anxiolytic activity.
The nootropic activity was assessed by recording the effect of BF (10-50 mg/kg) on the transfer latency, anxiolytic activity was evaluated by measuring the effect on duration of occupancy in the open arm.
The studies showed that BF possesses anxiolytic activity and nootropic activity.
BF inhibited baclofen-induced hypothermia and passivity.
Thus the study suggests that saponins act by modifying GABA ergic mechanism.
An elevated plus maze was used for assessment of both nootropic and anxiolytic activity.
The nootropic activity was assessed by recording the effect of BF (10-50 mg/kg) on the transfer latency, anxiolytic activity was evaluated by measuring the effect on duration of occupancy in the open arm.
The studies showed that BF possesses anxiolytic activity and nootropic activity.
BF inhibited baclofen-induced hypothermia and passivity.
Thus the study suggests that saponins act by modifying GABA ergic mechanism.
Publication
Authors
K.N. Gujar, S.B. Kasture
Keywords
anxiety, baclofen, behavior, n-butenolic fraction (BF)
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