Articles
PHYTOCHEMICAL AND ANTIMALARIAL STUDIES ON SWERTIA ALATA ROYLE
Article number
675_20
Pages
139 – 145
Language
English
Abstract
Different species of genus Swertia are used in different countries for a variety of ailments including malaria.
More than 85 xanthones and 17 secoiridoid bitters have been isolated from different species of Swertia. In the present study, the whole plant of Swertia alata Royle was investigated and three xanthones 1,8-dihydroxy-3,7-dimethoxyxanthone, 1,7,8-trihydroxy-3-methoxyxanthone and 1-hydroxy-3,7,8-trimethoxyxanthone were isolated from different extracts.
The total methanolic extract, its hexane soluble portion, chloroform soluble portion of petroleum ether extract and three isolated xanthones were tested in vitro at different dose levels for antimalarial activity.
The activity was expressed as percent invasion inhibition of the tested parasite.
The results indicated that all extracts and xanthones possessed some protective effect, however only 1,8-dihydroxy-3,7-dimethoxyxanthone exhibited significant activity and was therefore, further tested in vivo in Plasmodium berghei test model. 1,8-dihydroxy-3,7-dimethoxyxanthone produced the most significant reduction in percent parasitaemia at 10 mg/kg dose level.
More than 85 xanthones and 17 secoiridoid bitters have been isolated from different species of Swertia. In the present study, the whole plant of Swertia alata Royle was investigated and three xanthones 1,8-dihydroxy-3,7-dimethoxyxanthone, 1,7,8-trihydroxy-3-methoxyxanthone and 1-hydroxy-3,7,8-trimethoxyxanthone were isolated from different extracts.
The total methanolic extract, its hexane soluble portion, chloroform soluble portion of petroleum ether extract and three isolated xanthones were tested in vitro at different dose levels for antimalarial activity.
The activity was expressed as percent invasion inhibition of the tested parasite.
The results indicated that all extracts and xanthones possessed some protective effect, however only 1,8-dihydroxy-3,7-dimethoxyxanthone exhibited significant activity and was therefore, further tested in vivo in Plasmodium berghei test model. 1,8-dihydroxy-3,7-dimethoxyxanthone produced the most significant reduction in percent parasitaemia at 10 mg/kg dose level.
Publication
Authors
M. Karan, S. Bhatnagar, P. Wangtak, K. Vasisht
Keywords
in vivo test, in vitro test, plant extracts, xanthones
Online Articles (32)