THE EFFICIENCY OF POLYSACCHARIDE GEL EXTRACTED FROM FRUIT-HULLS OF DURIAN (DURIO ZIBETHINUS L.) FOR WOUND HEALING IN PIG SKIN

Polysaccharide gel (PG) extracted from fruit-hulls of durian (Durio zibethinus L.) was prepared as a preparation of dressing film.
Efficacy of PG film for the treatment of full-thickness excisional wounds was performed in swine.
Six young-female, cross-bred pigs, weighing 18-20 kg were used.
Three full-thickness excisional wounds 2.45 cm in diameter were operated along both sides of dorsal midline area in each pig.
Thirty-six wounds were randomly devided into 3 groups of 12 wounds.
All wounds in group 1 were applied 1% Lugol’s solution and covered with sterile gauze dressing (control). The wounds in group 2 and 3 were treated with PG dressing film (treatment 1) and applied 1% Lugol’s solution and covered with PG dressing film (treatment 2), respectively.
The wounds were examined for performance of wound healing on day 3, 6, 9, 12 and 15 postoperation and each group were re-treated with the same procedure.
On day 18, skin samples from each wound were taken for histopathological study.
The results demonstrated that PG dressing film treated wounds (treatment 1) showed more rapid wound closure, slightly and less tissue reactions than those in the control and the treatment 2 groups.
The results suggest that PG dressing film seems to have beneficial property on wound healing in pig skin in this study.

III WOCMAP Congress on Medicinal and Aromatic Plants – Volume 5: Quality, Efficacy, Safety, Processing and Trade in Medicinal and Aromatic Plants

P. Chansiripornchai, C. Pramatwinai, A. Rungsipipat, S. Ponsamart, O. Nakchat

durian dressing film, durian fruit-hull extract, polysaccharide gel, pig, wound healing

https://doi.org/10.17660/ActaHortic.2005.679.5