Articles
ISOLATION OF PRENYLFLAVONOIDS FROM HOPS
Article number
1010_15
Pages
131 – 140
Language
English
Abstract
Hops are a rich source of prenylflavonoids.
Some of them are showing remarkable pharmacological potential, e.g. xanthohumol (broad range of various activities) or 8-prenylnaringenin (most active phytoestrogen currently known). By extraction of hops with ethanol and fractionation of the resulting extract with supercritical carbon dioxide it is possible to separate the prenylflavonoids from other hop polyphenols and from most of the bitter acids.
By selective adsorption on polyvinylpolypyrrolidone (PVPP) the prenylflavonoids can be further enriched.
This results in an extract (Xantho-Flav) with a Xanthohumol content up to 85% which contains the whole spectrum of different hop prenylflavonoids.
Therefore it can serve as suitable source for isolating single compounds.
By only one recrystallization step it is possible to produce Xantho-Pure in purity above 90%. Extracts containing xanthohumol and other prenylflavonoids at different concentrations are currently tested in various in vivo trials investigating different pharmacological activities (e.g. with regard to hormone replacement therapy, cancer chemoprevention or prevention of atherosclerosis). Xantho-Pure can also serve as suitable starting material for production of 8-prenlynaringenin by two step chemical synthesis (isomerisation followed by demethylation).
Some of them are showing remarkable pharmacological potential, e.g. xanthohumol (broad range of various activities) or 8-prenylnaringenin (most active phytoestrogen currently known). By extraction of hops with ethanol and fractionation of the resulting extract with supercritical carbon dioxide it is possible to separate the prenylflavonoids from other hop polyphenols and from most of the bitter acids.
By selective adsorption on polyvinylpolypyrrolidone (PVPP) the prenylflavonoids can be further enriched.
This results in an extract (Xantho-Flav) with a Xanthohumol content up to 85% which contains the whole spectrum of different hop prenylflavonoids.
Therefore it can serve as suitable source for isolating single compounds.
By only one recrystallization step it is possible to produce Xantho-Pure in purity above 90%. Extracts containing xanthohumol and other prenylflavonoids at different concentrations are currently tested in various in vivo trials investigating different pharmacological activities (e.g. with regard to hormone replacement therapy, cancer chemoprevention or prevention of atherosclerosis). Xantho-Pure can also serve as suitable starting material for production of 8-prenlynaringenin by two step chemical synthesis (isomerisation followed by demethylation).
Publication
Authors
M. Biendl
Keywords
hop extract, hop polyphenols, xanthohumol, 8-prenylnaringenin
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