Articles
Evaluation and commercialisation process of natural solutions for postharvest decay
Article number
1451_17
Pages
117 – 126
Language
English
Abstract
Postharvest control of different pathogens is mainly dependent on traditional methods of preservation that often involve the use of synthetic pesticides.
However, these are more and more under pressure and, as a result, the need for pesticides from natural origin is constantly increasing.
Nevertheless, such green chemistry treatments hardly ever make it to the market.
When evaluating a new natural active ingredient or technology a systematic approach is essential to ensure safety, efficacy, and suitability for various applications.
The overall process used at Janssen PMP for such an evaluation is the same for synthetic and natural products and begins with a theoretical assessment, gathering information from scientific literature, patents, and regulatory approvals.
This is followed by a high-level evaluation, which involves testing a sample of the product.
This includes efficacy testing through controlled in vitro and in vivo studies to assess effectiveness and potential phytotoxicity.
Analytical, stability and compatibility tests are conducted to observe product behaviour under different conditions.
Concurrently, other departments conduct evaluations: the legal and regulatory affairs team assesses registration requirements, while the supply chain department examines production processes for scalability.
The commercial department investigates market potential and interest in the product.
If the initial high-level assessments yield positive results, more specialized evaluations commence.
This phase includes extensive efficacy testing, field trials, toxicological and ecotoxicological assessments, residue testing, and evaluations of environmental fate.
Additionally, considerations for the best registration route, production scale-up, packaging, and transport are also addressed.
This paper will go through these different processes and steps, highlighting where the pitfalls are and where most of these natural products fail.
However, these are more and more under pressure and, as a result, the need for pesticides from natural origin is constantly increasing.
Nevertheless, such green chemistry treatments hardly ever make it to the market.
When evaluating a new natural active ingredient or technology a systematic approach is essential to ensure safety, efficacy, and suitability for various applications.
The overall process used at Janssen PMP for such an evaluation is the same for synthetic and natural products and begins with a theoretical assessment, gathering information from scientific literature, patents, and regulatory approvals.
This is followed by a high-level evaluation, which involves testing a sample of the product.
This includes efficacy testing through controlled in vitro and in vivo studies to assess effectiveness and potential phytotoxicity.
Analytical, stability and compatibility tests are conducted to observe product behaviour under different conditions.
Concurrently, other departments conduct evaluations: the legal and regulatory affairs team assesses registration requirements, while the supply chain department examines production processes for scalability.
The commercial department investigates market potential and interest in the product.
If the initial high-level assessments yield positive results, more specialized evaluations commence.
This phase includes extensive efficacy testing, field trials, toxicological and ecotoxicological assessments, residue testing, and evaluations of environmental fate.
Additionally, considerations for the best registration route, production scale-up, packaging, and transport are also addressed.
This paper will go through these different processes and steps, highlighting where the pitfalls are and where most of these natural products fail.
Authors
W. Schotsmans, M. de Bolle
Keywords
pesticides, synthetic, natural, evaluation
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