Articles
CANCER PREVENTIVE POTENTIALS OF VEGETABLES AND FRUITS FROM SOUTHEAST ASIA AND SOME OF THEIR ACTIVE CONSTITUENTS
Article number
467_4
Pages
45 – 54
Language
Abstract
A total of 112 species of edible plants (122 samples) from Thailand were randomly collected, and their methanol-extracts screened for in vitro anti-tumor promoting activity using the inhibition test of tumor promoter-induced Epstein-Barr virus (EBV) activation in Raji cells.
It was found that 60% of these extracts inhibited EBV activation by 30% or more at a concentration of 200 mg/ml.
It should be noted that the ratio was markedly higher than that (26%) previously observed in common edible plants in Japan.
The species in the families Labiatae, Piperaceae, Rutaceae and Zingiberaceae were promising sources of effective anti-tumor promoters.
In addition, anti-tumor promoting effects of two active constituents, 1,2-di-O–
-linolenoyl-3-O–
-galactopyranosyl-sn-glycerol (DLGG, Citrus hystrix), and 1′-acetoxychavicol acetate (ACA, Languas galanga), together with their possible mode of action investigated thus far, are described.
It was found that 60% of these extracts inhibited EBV activation by 30% or more at a concentration of 200 mg/ml.
It should be noted that the ratio was markedly higher than that (26%) previously observed in common edible plants in Japan.
The species in the families Labiatae, Piperaceae, Rutaceae and Zingiberaceae were promising sources of effective anti-tumor promoters.
In addition, anti-tumor promoting effects of two active constituents, 1,2-di-O–
-linolenoyl-3-O–-galactopyranosyl-sn-glycerol (DLGG, Citrus hystrix), and 1′-acetoxychavicol acetate (ACA, Languas galanga), together with their possible mode of action investigated thus far, are described.
Authors
K. Koshimizu, A. Murakami, H. Ohigashi
Keywords
cancer prevention, Citrus hystrix, bitter orange, Languas galanga, great galangal, glyceroglycolipid, acetoxychavicol acetate
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