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Articles

TRYPANOCIDAL ACTIVITY FROM TABERNAEMONTANA CATHARINENSIS A. DC

Article number
501_24
Pages
165 – 170
Language
Abstract
Seeking for new chemopreventive and chemotherapeutic agents effective against Chagas’ disease, the efficacy of extracts, purified fractions and two indole alkaloids isolated from Tabernaemontana catharinensis was tested in vitro against trypomastigotes of Trypanosoma cruzi. It was verified through TLC that fractions mainly consisting of alkaloids exhibited increased activities.
The two indole alkaloids isolated from the root bark, heyneanine and 12-methoxy-4-methylvoachalotine displayed an LC50 of 890.89 and 356,73 μg/mL, respectively.
The positive control crystal violet showed an LC50 of 31 μg/mL.

Publication
II WOCMAP Congress Medicinal and Aromatic Plants, Part 2: Pharmacognosy, Pharmacology, Phytomedicine, Toxicology
Authors
S. Pereira, D.A. Dias, S.V. Sampaio, S.C. França, M.P.A. Toldo, S. Albuquerque
Keywords
Apocynaceae, Tabernaemontana, indole alkaloids, Chagas’ disease
Full text
https://doi.org/10.17660/ActaHortic.1999.501.24
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