Articles
ANTIMUTAGENIC ACTIVITY OF SOME SALVIA SPECIES WILDLY GROWING IN ERZURUM
Article number
826_8
Pages
65 – 72
Language
English
Abstract
The Ames-Salmonella/microsome mutagenicity assay is also used to designate antimutagens and anticarcinogens that are removing the mutagen and carcinogen effects of many chemicals, including drugs and biocides.
The objective of this study was to evaluate the antimutagenic potential of methanol extracts of S. limbata, S. nemerosa and S. verticillata plants by studying their effects on histidine requiring strains of Salmonella typhimurium TA1538 and TA 1535, bacterial strains in the absence and presence of a liver metabolizing system, S9-mix.
These plants extract indicated important dose dependent inhibition against 4-Nitroquinoline-1-oxide and sodium azide mutagens.
In the study with S9 it was determined weak positive effect of S. limbata against 2-aminoflourene.
As related to these results with the detailed studies of plant originated compounds it can be possible to change them into more useful products for men.
The objective of this study was to evaluate the antimutagenic potential of methanol extracts of S. limbata, S. nemerosa and S. verticillata plants by studying their effects on histidine requiring strains of Salmonella typhimurium TA1538 and TA 1535, bacterial strains in the absence and presence of a liver metabolizing system, S9-mix.
These plants extract indicated important dose dependent inhibition against 4-Nitroquinoline-1-oxide and sodium azide mutagens.
In the study with S9 it was determined weak positive effect of S. limbata against 2-aminoflourene.
As related to these results with the detailed studies of plant originated compounds it can be possible to change them into more useful products for men.
Authors
T. Özbek, O. Bariş, M. Güllüce, F. Sahin, H. Özkan, O.F. Anakok
Keywords
Salvia, AMES, antimutagenicity, S-9 microsomal fraction
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