Articles
EFFECTS OF AN ANCIENT NUTRITIONAL SUPPLEMENT CHYAWANPRASH AND VITAMIN C ON ANTIOXIDANT ENZYMES AND SERUM IMMUNOGLOBULIN G LEVELS IN HUMANS
Article number
972_8
Pages
61 – 66
Language
English
Abstract
Chyawanprash is an ancient Indian dietary supplement mainly containing vitamin C (34 mg/100 g) derived from amla (Indian gooseberry) (Emblica officinalis). It is a proven energizer, immunity booster and pre-emptive tonic with multiple health benefits.
Since oxidative stress is the cause or the consequence of multiple patho-physiologies, we first wanted to establish the effects of chyawanprash on the antioxidant status.
The overlapping chemical composition and recommended uses of vitamin C one of the most effective dietary antioxidant and chyawanprash the most popular ancient nutritional supplement used even today made us to compare the both.
Our objectives were 1. to study the effects of chyawanprash and vitamin C on antioxidant enzymes and serum immunoglobulin, 2. to compare the effects of chyawanprash and vitamin C on the antioxidant enzymes and serum immunoglobulin G. Twelve healthy adult males were divided randomly into two groups of six subjects each.
Group 1 received vitamin C (500 mg/d) and group 2 received chyawanprash (15 g/d) explanation next pg for eight weeks.
At the start and end of the dietary period erythrocyte glutathione peroxidase (GPX), erythrocyte superoxide dismutase (SOD) and serum immunoglobulin G (IgG) levels were measured.
Significant increase in the erythrocyte SOD activity from 1.41±0.16×103 to 1.77±0.29×103 U/gmHb in group 2 but not in group 1. In both the groups there was a significant decrease in serum IgG levels with the values still with in the normal range.
This enhancement of antioxidant status at a level better than vitamin C gives us a platform for starting to understand the mechanism for chyawanprash related multiple health benefits.
The decrease in serum IgG levels might be beneficial.
It is hypothesized to be due to improvement in the entrapment of antigens by the liver, or gut associated lymphoid tissue brought by both the supplements, giving us idea for future studies.
Since oxidative stress is the cause or the consequence of multiple patho-physiologies, we first wanted to establish the effects of chyawanprash on the antioxidant status.
The overlapping chemical composition and recommended uses of vitamin C one of the most effective dietary antioxidant and chyawanprash the most popular ancient nutritional supplement used even today made us to compare the both.
Our objectives were 1. to study the effects of chyawanprash and vitamin C on antioxidant enzymes and serum immunoglobulin, 2. to compare the effects of chyawanprash and vitamin C on the antioxidant enzymes and serum immunoglobulin G. Twelve healthy adult males were divided randomly into two groups of six subjects each.
Group 1 received vitamin C (500 mg/d) and group 2 received chyawanprash (15 g/d) explanation next pg for eight weeks.
At the start and end of the dietary period erythrocyte glutathione peroxidase (GPX), erythrocyte superoxide dismutase (SOD) and serum immunoglobulin G (IgG) levels were measured.
Significant increase in the erythrocyte SOD activity from 1.41±0.16×103 to 1.77±0.29×103 U/gmHb in group 2 but not in group 1. In both the groups there was a significant decrease in serum IgG levels with the values still with in the normal range.
This enhancement of antioxidant status at a level better than vitamin C gives us a platform for starting to understand the mechanism for chyawanprash related multiple health benefits.
The decrease in serum IgG levels might be beneficial.
It is hypothesized to be due to improvement in the entrapment of antigens by the liver, or gut associated lymphoid tissue brought by both the supplements, giving us idea for future studies.
Authors
N. Gupta, S.C. Mahapatra
Keywords
chyawanprash, vitamin C, antioxidant, GPX, SOD, IgG
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