Articles
ANTI-HYPERGLYCEMIC AGENTS FROM TROPICAL PLANT EXTRACTS
Article number
1040_32
Pages
231 – 237
Language
English
Abstract
Preliminary investigations on 15 plant extracts (ethanolic and aqueous extraction) identified as high antioxidants and having a significant total phenolic content were also seen to have α-amylase and α-glucosidase activity.
A correlation between the anti-hyperglycemic activity, total phenolic content and antioxidant (DPPH) activity was established.
To further substantiate these findings, known phenolic compounds, its antioxidant activity and α-amylase and α-glucosidase activity were determined.
The possibility of tannins binding non-specifically to the enzymes thus contributing to the anti-hyperglycemic activity was also investigated.
Our study clearly indicated that anti-hyperglycemic activity observed in the plant extracts was indeed not due to tannins non-specific absorption.
A correlation between the anti-hyperglycemic activity, total phenolic content and antioxidant (DPPH) activity was established.
To further substantiate these findings, known phenolic compounds, its antioxidant activity and α-amylase and α-glucosidase activity were determined.
The possibility of tannins binding non-specifically to the enzymes thus contributing to the anti-hyperglycemic activity was also investigated.
Our study clearly indicated that anti-hyperglycemic activity observed in the plant extracts was indeed not due to tannins non-specific absorption.
Publication
Authors
U.D. Palanisamy, T. Manaharan, T. Masilami
Keywords
type 2 diabetes mellitus, α-glucosidase, α-amylase, antioxidant, total phenolic content, tannins
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