Articles
SULFORAPHANE PROTECTS CORTICAL NEURONS AGAINST ENDOGENOUS NEUROTOXINS IN A MODEL OF PARKINSON’S DISEASE
Article number
1040_47
Pages
341 – 348
Language
English
Abstract
The endogenous neurotoxin 5-S-cysteinyl-dopamine (CysDA) has been linked to the degeneration of dopaminergic neurons in the Substantia nigra. Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables that has been proposed as a potential chemopreventive agent, although its effects on other cells are less clear.
This study was undertaken to investigate the protective effects of SFN against CysDA-induced injury in primary cortical neurons.
The results indicate that SFN protects primary cortical neurons against CysDA-induced injury by a mechanism involving the increased nuclear translocation of Nrf2 and the increased activity of phase II enzymes such as glutathione-S-transferase, glutathione reductase, and thioredoxine reductase.
Moreover, the protection exerted by SFN appears to be mediated by the activation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) and Akt/protein kinase B (PKB) pathways.
This study was undertaken to investigate the protective effects of SFN against CysDA-induced injury in primary cortical neurons.
The results indicate that SFN protects primary cortical neurons against CysDA-induced injury by a mechanism involving the increased nuclear translocation of Nrf2 and the increased activity of phase II enzymes such as glutathione-S-transferase, glutathione reductase, and thioredoxine reductase.
Moreover, the protection exerted by SFN appears to be mediated by the activation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) and Akt/protein kinase B (PKB) pathways.
Publication
Authors
D. Vauzour, M. Buonfiglio, G. Corona, J. Chirafisi, K. Vafeiadou, C. Angeloni, S. Hrelia, P. Hrelia, J.P.E. Spencer
Keywords
5-S-Cysteinyl-dopamine, antioxidant response element, Parkinson’s disease, neurodegeneration, sulforaphane
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