Articles
PREVENTIVE AND CURATIVE ANTICANCER DRUG. APPLICATION TO CROWN-GALL TUMORS
Article number
125_31
Pages
239 – 248
Language
Abstract
We describe the in vivo antitumor effect of the compound BG-8 on the induction and/or development of Agrobacterium tumefaciens – induced tumors on pea seedlings and Chrysanthemum plantlets.
A single treatment applied before or after bacterial infection leads to a strong tumor-weight decrease without affecting the plant growth.
The BG-8 inhibitory effect depends on the duration of treatment and compound concentration. In vitro this substance prevents cancer DNA synthesis and this explains the inhibition of tumor cell multiplication.
There is little or no effect on healthy cell DNA in vitro synthesis.
A single treatment applied before or after bacterial infection leads to a strong tumor-weight decrease without affecting the plant growth.
The BG-8 inhibitory effect depends on the duration of treatment and compound concentration. In vitro this substance prevents cancer DNA synthesis and this explains the inhibition of tumor cell multiplication.
There is little or no effect on healthy cell DNA in vitro synthesis.
Publication
Authors
M. Beljanski, L. Le Goff, A. Faivre-Amiot
Keywords
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