Articles
Application of Asteraceae multi-omics database in artemisinin biosynthesis research
Article number
1462_6
Pages
47 – 52
Language
English
Abstract
Artemisinin, a sesquiterpene lactone derived from Artemisia annua, remains one of the most effective antimalarial compounds.
Advances in multi-omics technologies have provided new opportunities to elucidate the biosynthetic pathway and regulatory mechanisms underlying artemisinin production.
The Asteraceae Multi-omics Information Resource (AMIR; https://yanglab.hzau.edu.cn/AMIR/) integrates genomic, transcriptomic, metabolomic and variation data from 74 Asteraceae species, enabling systematic investigations into terpene synthases (TPS), cytochrome P450 monooxygenases (CYPs), and other enzymes involved in artemisinin biosynthesis.
Here, we present an overview of AMIR and highlight its application in artemisinin research.
Strategies include mining candidate genes, correlating gene expression with metabolite accumulation, and comparative evolutionary analysis of biosynthetic pathways.
Case studies demonstrate the potential of AMIR to accelerate synthetic biology and molecular breeding approaches.
This work provides a foundation for developing artemisinin-related research and breeding practices in the Asteraceae family.
Advances in multi-omics technologies have provided new opportunities to elucidate the biosynthetic pathway and regulatory mechanisms underlying artemisinin production.
The Asteraceae Multi-omics Information Resource (AMIR; https://yanglab.hzau.edu.cn/AMIR/) integrates genomic, transcriptomic, metabolomic and variation data from 74 Asteraceae species, enabling systematic investigations into terpene synthases (TPS), cytochrome P450 monooxygenases (CYPs), and other enzymes involved in artemisinin biosynthesis.
Here, we present an overview of AMIR and highlight its application in artemisinin research.
Strategies include mining candidate genes, correlating gene expression with metabolite accumulation, and comparative evolutionary analysis of biosynthetic pathways.
Case studies demonstrate the potential of AMIR to accelerate synthetic biology and molecular breeding approaches.
This work provides a foundation for developing artemisinin-related research and breeding practices in the Asteraceae family.
Publication
Authors
Y. Liu, L. He, Z. Mei
Keywords
artemisinin, Asteraceae, multi-omics database, terpene synthase, cytochrome P450, synthetic biology
Online Articles (28)