Articles
Development of technologies for xanthone powder production from mangosteen
Article number
1186_28
Pages
185 – 188
Language
English
Abstract
The objective of this research was to produce xanthones, a group of bioactive substances, specifically alpha-, beta- and gamma-mangostin, from mangosteen rind and to produce mangosteen products.
Extraction of xanthone was done by solvent extraction using ethanol, methanol, ethyl acetate and water.
Ethanol and methanol extracted 21.75-24.33 and 20.8-22.8% of the dried mangosteen rind, respectively.
A mixture of ethyl acetate and water (1:1, v/v) extracted 7.8-10.36% of the dried mangosteen rind.
Analysis of xanthone by using LC-MS showed that 1 g dried mangosteen rind contained 931.79 µg alpha-mangostin, 19.47 µg beta-mangostin and 18.7 µg gartanins.
One gram of the methanol extract contained 1079.72 µg alpha-mangostin, 21.10 µg beta-mangostin and 24.17 µg gartanins.
One gram of the ethyl acetate extract contained 782.74 µg alpha-mangostin, 19.69 µg beta-mangostin and 26.04 µg gartanins.
Toxicity tests of the bioactive compounds against cancer cells, MCF7-Breast cancer, showed that the average IC50 was 17.35 µg mL-1. Xanthone powder was manufactured from ethanol and water extract by using a spray dryer.
Mangosteen pulp was processed to produce instant mangosteen powder, which can be mixed with tea and coffee or used to make cookies and ice cream.
Extraction of xanthone was done by solvent extraction using ethanol, methanol, ethyl acetate and water.
Ethanol and methanol extracted 21.75-24.33 and 20.8-22.8% of the dried mangosteen rind, respectively.
A mixture of ethyl acetate and water (1:1, v/v) extracted 7.8-10.36% of the dried mangosteen rind.
Analysis of xanthone by using LC-MS showed that 1 g dried mangosteen rind contained 931.79 µg alpha-mangostin, 19.47 µg beta-mangostin and 18.7 µg gartanins.
One gram of the methanol extract contained 1079.72 µg alpha-mangostin, 21.10 µg beta-mangostin and 24.17 µg gartanins.
One gram of the ethyl acetate extract contained 782.74 µg alpha-mangostin, 19.69 µg beta-mangostin and 26.04 µg gartanins.
Toxicity tests of the bioactive compounds against cancer cells, MCF7-Breast cancer, showed that the average IC50 was 17.35 µg mL-1. Xanthone powder was manufactured from ethanol and water extract by using a spray dryer.
Mangosteen pulp was processed to produce instant mangosteen powder, which can be mixed with tea and coffee or used to make cookies and ice cream.
Authors
W. Limphapayom, K. Satayawut, W. Wattanavichit, A. Pisalwadcharin, S. Sukhasem
Keywords
xanthone, extract, mangosteen rind, production, mangosteen powder
Groups involved
Online Articles (37)