Articles
ANTI-OBESITY EFFECT OF ALLENE CAROTENOIDS, FUCOXANTHIN AND NEOXANTHIN FROM SEAWEEDS AND VEGETABLES
Article number
841_18
Pages
167 – 172
Language
English
Abstract
Obesity is one of the most prevalent nutritional disorders, and it results from an imbalance between energy intake and expenditure.
We have found that carotenoids containing an allene bond, such as fucoxanthin and fucoxanthinol, showed anti-obesity effects with a new molecular mechanism.
We showed significant reduction of WAT in wistar rats and obese KK-Ay mice by feeding both carotenoids.
Clear signals of UCP1 protein and mRNA were detected by Western and Northern blot analyses in WAT in mice fed fucoxanthin, although there is little expression of UCP1 in WAT in mice fed the control diet.
UCP1 expression in WAT by fucoxanthin intake leads to oxidation of fatty acids and heat production in WAT mitochondria.
The substrate oxidation can directly reduce WAT in animals.
We also found a relationship between carotenoid structure and anti-obesity properties, i.e., ability to suppress adipocyte differentiation.
An examination of structure and function revealed that carotenoids containing an allene bond and an additional hydroxyl substituent on the side group show suppressive effects on adipocyte differentiation in 3T3-L1 cells.
These findings show a great potential for application in the field of therapeutics for the development of novel anti-obesity compounds.
Further, the suggestion that carotenoid health effects are likely linked to structural characteristics may help in the discovery of additional carotenoids that possess health-promoting properties.
We have found that carotenoids containing an allene bond, such as fucoxanthin and fucoxanthinol, showed anti-obesity effects with a new molecular mechanism.
We showed significant reduction of WAT in wistar rats and obese KK-Ay mice by feeding both carotenoids.
Clear signals of UCP1 protein and mRNA were detected by Western and Northern blot analyses in WAT in mice fed fucoxanthin, although there is little expression of UCP1 in WAT in mice fed the control diet.
UCP1 expression in WAT by fucoxanthin intake leads to oxidation of fatty acids and heat production in WAT mitochondria.
The substrate oxidation can directly reduce WAT in animals.
We also found a relationship between carotenoid structure and anti-obesity properties, i.e., ability to suppress adipocyte differentiation.
An examination of structure and function revealed that carotenoids containing an allene bond and an additional hydroxyl substituent on the side group show suppressive effects on adipocyte differentiation in 3T3-L1 cells.
These findings show a great potential for application in the field of therapeutics for the development of novel anti-obesity compounds.
Further, the suggestion that carotenoid health effects are likely linked to structural characteristics may help in the discovery of additional carotenoids that possess health-promoting properties.
Publication
Authors
K. Miyashita, H. Maeda, T. Tsukui, T. Okada, M. Hosokawa
Keywords
UCP1, WAT, adipocyte differentiation, seaweed, green vegetables
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