Articles
TART CHERRY INTAKE REDUCES INDICES OF METABOLIC SYNDROME IN RATS
Article number
841_25
Pages
215 – 220
Language
English
Abstract
Elevated plasma lipids, glucose, insulin and fatty liver are among components of metabolic syndrome, a phenotypic pattern which typically precedes the development of Type II diabetes.
Animal studies show that intake of anthocyanins reduces hyperlipidemia, obesity, and atherosclerosis.
However, studies using physiologically relevant, whole food sources of anthocyanins are limited.
Tart cherries are a rich source of anthocyanins and cherry intake may confer biologic effects.
This hypothesis was tested in the Dahl Salt-Sensitive rat of insulin resistance and hyperlipidemia.
Dahl rats were pair-fed AIN-76a-based diets supplemented with either 1% freeze-dried whole tart cherry (w/w) or with 0.85% additional carbohydrate to match macronutrient and calorie provision.
The groups were compared after 90 days.
The cherry-enriched diet was associated with reduced fasting hyperlipidemia, hyperinsulinemia, and reduced fatty liver.
Cherry diets were also associated with enhanced hepatic peroxisome proliferator-activated receptor PPAR-
and PPAR-
expression and increased plasma antioxidant capacity.
In conclusion, physiologically relevant tart cherry consumption reduced several phenotypic risk factors for metabolic syndrome.
Tart cherries may represent a whole food research model of the health effects of anthocyanin-rich foods, and may possess nutraceutical value against risk factors for metabolic syndrome and its clinical sequelae.
Animal studies show that intake of anthocyanins reduces hyperlipidemia, obesity, and atherosclerosis.
However, studies using physiologically relevant, whole food sources of anthocyanins are limited.
Tart cherries are a rich source of anthocyanins and cherry intake may confer biologic effects.
This hypothesis was tested in the Dahl Salt-Sensitive rat of insulin resistance and hyperlipidemia.
Dahl rats were pair-fed AIN-76a-based diets supplemented with either 1% freeze-dried whole tart cherry (w/w) or with 0.85% additional carbohydrate to match macronutrient and calorie provision.
The groups were compared after 90 days.
The cherry-enriched diet was associated with reduced fasting hyperlipidemia, hyperinsulinemia, and reduced fatty liver.
Cherry diets were also associated with enhanced hepatic peroxisome proliferator-activated receptor PPAR-
and PPAR- expression and increased plasma antioxidant capacity.In conclusion, physiologically relevant tart cherry consumption reduced several phenotypic risk factors for metabolic syndrome.
Tart cherries may represent a whole food research model of the health effects of anthocyanin-rich foods, and may possess nutraceutical value against risk factors for metabolic syndrome and its clinical sequelae.
Publication
Authors
E.M. Seymour, A.A.M. Singer, A. Kirakosyan, D.E. Urcuyo-Llanes, P.B. Kaufman, S.F. Bolling
Keywords
Prunus cereus, anthocyanin, cholesterol, antioxidant, diabetes
Online Articles (99)