Articles
ANALYSE BIOLOGIQUE ET PHYTOTHERAPIE CLINIQUE DE L’ASTHME DANS UNE POPULATION DE LA TUNISIE CENTRALE
Article number
853_48
Pages
395 – 396
Language
English
Abstract
Previous studies have reported that Asthma prevalence can reach 6.5% in the Tunisian population.
Asthma morbidity is not only associated to the cost of the disease care but also to its highly increasing incidence among low-incomes populations.
In this study, we investigated biological and molecular analysis of alpha 1 antitrypsin marker associated with asthma.
A total of 96 asthmatic patients attending the pneumology services in central tunisian hospitals were analyzed.
Alpha 1 antitrypsin phenotypes were determined by immunoturbidimetric quantification of plasma AAT and isoelectrofocusing of sera at pH 4-6 on polyacrylamide gel.
Genotyping was performed by RFLP PCR. Mean plasma AAT level was 2.01±0.73 g/L. Allelic frequencies of the PiM1, PiM2, PiM3, PiS and PiZ AAT variants were 0.739, 0.229, 0.015, 0.01 and 0.005, respectively.
On the other hand, a therapeutic measure survey for asthma was established.
Treatment approach includes beta-2-mimetic, xanthic bases (theophylline) and corticoids administration during the disease evolutionary stage.
However, it is generally held that this conventional treatments show various undesirable effects.
Alternatively, Clinical Phytotherapy may be of benefit to the asthmatic patients.
In fact, plants used in traditional medicine contain a wide range of ingredients that can be used to treat chronic as well as infectious diseases.
Extracts from Tymus vulgaris, Lavandula officinalis, Satirrea montana, Ribes nigrum, Eucalyptus globulus are the most effective in asthma phytotherapy.
The most important biological functions of the bioactive compounds of these plants are their anti-infectious effects. Plantago major, Fumaria officinalis are also of interest because of their antiallergic and choleritic properties.
Asthma morbidity is not only associated to the cost of the disease care but also to its highly increasing incidence among low-incomes populations.
In this study, we investigated biological and molecular analysis of alpha 1 antitrypsin marker associated with asthma.
A total of 96 asthmatic patients attending the pneumology services in central tunisian hospitals were analyzed.
Alpha 1 antitrypsin phenotypes were determined by immunoturbidimetric quantification of plasma AAT and isoelectrofocusing of sera at pH 4-6 on polyacrylamide gel.
Genotyping was performed by RFLP PCR. Mean plasma AAT level was 2.01±0.73 g/L. Allelic frequencies of the PiM1, PiM2, PiM3, PiS and PiZ AAT variants were 0.739, 0.229, 0.015, 0.01 and 0.005, respectively.
On the other hand, a therapeutic measure survey for asthma was established.
Treatment approach includes beta-2-mimetic, xanthic bases (theophylline) and corticoids administration during the disease evolutionary stage.
However, it is generally held that this conventional treatments show various undesirable effects.
Alternatively, Clinical Phytotherapy may be of benefit to the asthmatic patients.
In fact, plants used in traditional medicine contain a wide range of ingredients that can be used to treat chronic as well as infectious diseases.
Extracts from Tymus vulgaris, Lavandula officinalis, Satirrea montana, Ribes nigrum, Eucalyptus globulus are the most effective in asthma phytotherapy.
The most important biological functions of the bioactive compounds of these plants are their anti-infectious effects. Plantago major, Fumaria officinalis are also of interest because of their antiallergic and choleritic properties.
Authors
S. Denden, W. Braham, S. Gorcii Aloui, R. Lakhdar, H. Kahloun, K. Mahdouani, J. Knani, J. Ben Chibani, A. Haj Khelil
Keywords
alpha 1 antitrypsin, asthma, phytotherapy, conventional therapy
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