Deciphering genetic and epigenetic drivers of degeneration in the Austrian grape cultivar ‘Neuburger’

The Austrian grape cultivar ‘Neuburger’ (cultivated on 309 ha) increasingly exhibits symptoms of degenerative changes, characterized by shortened internodes, abnormal growth patterns, and eventual vine death.
This study aimed to investigate the genetic and epigenetic mechanisms underlying this degeneration.
The research included transcriptome analysis, qRT-PCR validations, and methylation-sensitive sequencing.
Differences in gene expression and DNA methylation were identified between symptomatic and healthy plants.
Notably, genes involved in gibberellin signaling pathways, such as VvGA2ox4, and transcription factors like WRKY40 showed significant expression differences.
Epigenetic analyses suggested stress responses potentially linked to environmental factors and agricultural practices.
The findings indicate that the degeneration results from a complex interaction between genetic predispositions and stress-induced responses.
These insights could inform strategies to enhance the resilience of ‘Neuburger’, such as targeted breeding or genetic optimization.
Further research is needed to deepen the understanding of these mechanisms and ensure sustainable cultivation of this traditional grape cultivar.

International Symposium on Biotechnological Tools in Horticulture

R. Hack, F. Regner

grapevine, gibberellins, qRT-PCR, RNA, sequencing

https://doi.org/10.17660/ActaHortic.2026.1454.27